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胰高血糖素样肽-1(GLP-1)是一种由30或31个氨基酸组成的肽激素,GLP-1在人体内以GLP-1(7-36)和GLP-1(7-37)两种活性形式存在。
Glucagon-like peptide-1(GLP-1)is a 30- or 31-amino-cacid-long peptide hormone.GLP-1 exists in two equally bioactive forms,GLP-1 (7-37 )amide and GLP-1 (7-36) amide.
GLP-1是一种肠促胰岛素,由胰高血糖素原基因编码合成,主要由肠道 L 细胞产生,有些也可由后脑神经元产生。
GLP-1 is a biological product derived from the post-translational processing of proglucagon,GLP-1 is secreted by the enteroentocrine L cells,but also by some neuronal populations in the hindbrain.
GLP-1可以增强胰岛素释放并降低胰高血糖素浓度。
GLP-1 potentiates insulin release and reduces glucagon's concentration in physiological conditions.