AG真人国际(中国)官方官网

|
|
EN
  • 业务咨询

    中国:

    Email: marketing@videisimo.net

    业务咨询专线:400-780-8018

    (仅限服务咨询,其他事宜请拨打川沙总部电话)

    川沙总部电话: +86 (21) 5859-1500

    海外:

    +1(626)986-9880(U.S. - West Coast)

    0044 7790 816 954 (Europe)

    Email:marketing@medicilon.com

在线留言×
点击切换
Customer Center
客户中心

合成一类新型选择性TNIK抑制剂并评估其抗结直肠癌作用,PK研究通过AG真人国际(中国)官方官网进行

2023-07-05
|
访问量:

The Traf2- and Nck-interacting protein kinase (TNIK) is a downstream signal protein of the Wnt/β-catenin pathway and has been thought of as a potential target for the treatment of colorectal cancer. SAR analysis leads to the identification of a number of potent TNIK inhibitors with Compound 21k being the most active one. Preliminary assessment for the pharmacokinetic properties of Compound 21k was carried out through services provided by Medicilon.

41.png

Reference:

Yueshan Li, et al. Discovery of 3,4-Dihydrobenzo[ f][1,4]oxazepin-5(2 H)-one Derivatives as a New Class of Selective TNIK Inhibitors and evalsuation of Their Anti-Colorectal Cancer Effects. J Med Chem. 2022 Feb 10;65(3):1786-1807.  doi: 10.1021/acs.jmedchem.1c00672.  

相关新闻