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研究人员设计并合成了一种光笼PI3K抑制剂1，它可以通过紫外线照射激活，释放出高效PI3K抑制剂2。化合物1和2的ADME研究通过AG真人国际(中国)官方官网进行

2023-07-05
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Aberrant activation of the PI3K pathway has been intensively targeted for cancer therapeutics for decades. In this work, researchers designed and synthesized a novel photocaged PI3K inhibitor 1, which could be readily activated by UV irradiation to release a highly potent PI3K inhibitor 2. 

ADME studies of compounds 1 and 2 were conducted by Medicilon. 

Medicilon's pharmacokinetics department offers the clients a broad spectrum of high quality of services in the areas of in vitro ADME, in vivo pharmacokinetics and bioanalysis services, ranging from small molecules to large molecules, such as protein and antibody.

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Reference:

Kehui Zhang, et al. Design, Synthesis, and Biological evalsuation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer Treatment. J Med Chem. 2021 Jun 10;64(11):7331-7340. doi: 10.1021/acs.jmedchem.0c02186. 

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